Summaries by Inventor Maher, Christopher

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

A long non-coding RNA in early and late-stage breast cancer as a prognostic marker, diagnostic marker, and therapeutic target.
Eteleeb, Abdallah ; Maher, Christopher ; Silva-Fisher, Jessica
T-020366

— Technology Description Researchers in Dr. Jessica Silva-Fisher’s laboratory have developed antisense oligonucleotide targeting a long non-coding RNA (lncRNA), LINC00355, as a treatment for late-stage relapse (LSR) breast cancer. LINC00355 is highly expressed in LSR breast cancer patients and…